Publications

Coexistence of Ammonium Transporter and Channel Mechanisms in Amt-Mep-Rh Twin-His Variants Impairs the Filamentation Signaling Capacity of Fungal Mep2 Transceptors. Williamson G, Brito AS, Bizior A, Tamburrino G, Dias Mirandela G, Harris T, Hoskisson PA, Zachariae U, Marini AM, Boeckstaens M, Javelle A. mBio 2022; 13(2):e0291321.
The TOR kinase pathway is relevant for nitrogen signaling and antagonism of the mycoparasite Trichoderma atroviride. Segreto R, Bazafkan H, Millinger J, Schenk M, Atanasova L, Doppler M, Büschl C, Boeckstaens M, Soto Diaz S, Schreiner U, Sillo F, Balestrini R, Schuhmacher R, Zeilinger S. PLoS One 2021;16(12):e0262180.
A two-lane mechanism for selective biological ammonium transport. Williamson G, Tamburrino G, Bizior A, Boeckstaens M, Dias Mirandela G, Bage M, Pisliakov A, Ives CM, Terras E, Hoskisson PA, Marini AM, Zachariae U and Javelle A. eLife 2020; 9:e57183.
Yeast filamentation signaling is connected to a specific substrate translocation mechanism of the Mep2 transceptor. Brito AS, Neuhäuser B, Wintjens R, Marini AM and Boeckstaens M. PLOS Genetics 2020; 16(2):e1008634.
Human apolipoprotein L1 interferes with mitochondrial function in Saccharomyces cerevisiae. Chidiac M, Daher J, Boeckstaens M, Poelvoorde P, Badran B, Marini AM, Khalaf R and Vanhamme L. Molecular Medicine Reports. 2020; doi: 10.3892/mmr.2020.11271.
Pib2-dependent feedback control of the TORC1 signaling network by the Npr1 kinase. Brito AS, Soto Diaz S, Van Vooren P, Godard P, Marini AM and Boeckstaens M. iScience 2019; 20: 415-433.
Ethanol sensitizes skeletal muscle to ammonia-induced molecular perturbations. Kant S, Davuluri G, Alchirazi KA, Welch N, Heit C, Kumar A, Gangadhariah M, Kim A, McMullen MR, Willard B, Luse DS, Nagy LE, Vasiliou V, Marini AM, Weiner ID and Dasarathy S. Journal of Biological Chemistry 2019 3; 294(18):7231-7244.
Nitrogen isotope signature evidences ammonium deprotonation as a common transport mechanism for the AMT-Mep-Rh protein superfamily. Ariz I, Boeckstaens M, Gouveia C, Martins AP, Sanz-Luque E, Fernández E, Soveral G, von Wirén N, Marini AM, Aparicio-Tejo PM and Cruz C. Science Advances 2018 ;4(9):eaar3599.
The metabolic waste ammonium regulates mTORC2 and mTORC1 signaling. Merhi A, Delrée P, Marini AM. Scientific Reports 2017 17;7:44602.
Yeast nitrogen catabolite repression is sustained by signals distinct from glutamine and glutamate reservoirs. Fayyad-Kazan M, Feller A, Bodo E, Boeckstaens M, Marini AM, Dubois E, Georis I. Molecular Microbiology 2016 99(2):360-79.
From the discovery of microbial Mep-Amt ammonium transporters to human Rhesus factors. Boeckstaens M. Médecine/Sciences 2016; 32(4):394-400.
Identification of a Novel Regulatory Mechanism of Nutrient Transport Controlled by TORC1-Npr1-Amu1/Par32. Boeckstaens M, Merhi A, Llinares E, Van Vooren P, Springael JY, Wintjens R, Marini AM. PLOS Genetics 2015 14;11(7):e1005382.
Wnt/β-Catenin Signaling Regulates the Expression of the Ammonium Permease Gene RHBG in Human Cancer Cells. Merhi A, De Mees C, Abdo R, Victoria Alberola J, Marini AM. PLOS One 2015 1;10(6): e0128683.
The General Amino Acid Permease FfGap1 of Fusarium fujikuroi Is Sorted to the Vacuole in a Nitrogen-Dependent, but Npr1 Kinase-Independent Manner. Pfannmüller A, Wagner D, Sieber C, Schönig B, Boeckstaens M, Marini AM, Tudzynski B. PLOS One 2015 24; 10(4):e0125487.
Ammonia excretion in Caenorhabditis elegans: mechanism and evidence of ammonia transport of the Rhesus protein CeRhr-1. Adlimoghaddam A, Boeckstaens M, Marini AM, Treberg JR, Brassinga AK, Weihrauch D. Journal of Experimental Biology 2015 218(Pt 5): 675-683.
The TORC1 effector kinase Npr1 fine tunes the inherent activity of the Mep2 ammonium transport protein. Boeckstaens M, Llinares E, Van Vooren P, Marini AM. Nature Communications 2014 5:3101.
SNPs altering ammonium transport activity of human Rhesus factors characterized by a yeast-based functional assay. Deschuyteneer A, Boeckstaens M, De Mees C, Van Vooren P, Wintjens R, Marini AM. PLOS One 2013 13;8(8):e71092.
A role for Rhesus factor Rhcg in renal ammonium excretion and male fertility. Biver S, Belge H, Bourgeois S, Van Vooren P, Nowik M, Scohy S, Houillier P, Szpirer J, Szpirer C, Wagner CA, Devuyst O, Marini AM. Nature 2008 20;456(7220):339-43.
Distinct transport mechanisms in yeast ammonium transport/sensor proteins of the Mep/Amt/Rh family and impact on filamentation. Boeckstaens M., André B. and Marini AM. Journal of Biological Chemistry 2008, 283: 21362-21370.
The yeast ammonium transport protein Mep2 and its positive regulator, the Npr1 kinase, play an important role in normal and pseudohyphal growth on various nitrogen media through retrieval of excreted ammonium. Boeckstaens M., André B. and Marini AM. Molecular Microbiology 2007, 64: 534-546.
Structural involvement in substrate recognition of an essential aspartate residue conserved in Mep/Amt and Rh-type ammonium transporters. Marini AM., Boeckstaens M., Benjelloun CZ., André B. Current Genetics 2006, 49: 364-374.
Transduction of the Nitrogen Signal Activating Gln3-mediated Transcription Is Independent of Npr1 Kinase and Rsp5-Bul1/2 Ubiquitin Ligase in Saccharomyces cerevisiae. Feller A., Boeckstaens M., Marini AM. and Dubois E. Journal of Biological Chemistry 2006, 281: 28546-28554.
From yeast ammonium transporters to Rhesus proteins. Marini AM., Boeckstaens M and André B. Transfusion clinique et biologique 2006, 13: 95-96.
Physiological role of the putative ammonium transporter RhCG in the mouse. Biver S., Scohy S., Szpirer J., Szpirer C., André B. and Marini AM. Transfusion clinique et biologique 2006, 13: 167-168.
In vivo functional characterization of the Escherichia coli ammonium channel AmtB: evidence formetabolic coupling of AmtB to glutamine synthetase. Javelle A., Thomas G., Marini AM., Krämer R. and Merrick M. Biochem. J. 2005, 390:215-222.
Characterisation of three functional high affinity ammonium transporters in Lotus japonicus with differential transcriptional regulation and spatial expression. D'Apuzzo E., Rogato A., Simon-Rosin U., El Alaoui H., Barbulova A., Betti M., Dimou M., Katinakis P., Marquez A., Marini AM., Udvardi KM. and Chiurazzi M. Plant Physiology 2004, 134:1763-1774.
Molecular characterization, function and regulation of ammonium transporters (Amt) and ammonium-metabolizing enzymes (GS, NADP-GDH) in the ectomycorrhizal fungus Hebeloma cylindrosporum. Javelle A., Morel M., Rodriguez-Pastrana BR., Botton B., André B., Marini AM., Brun A. and Chalot M. Molecular Microbiology 2003, 47:411-430.
Homo- and hetero-oligomerization of AMT1 NH4+-uniporters. Ludewig U., Wilken S., Wu B., Jost W., Obrdlik P., El Bakkoury M., Marini AM., André B., Hamacher T., Boles E., Von Wiren N. and Frommer WB. Journal of Biological Chemistry 2003, 278:45603-45610.
High-affinity ammonium transporters and nitrogen sensing in mycorrhizas. Javelle A., André B., Marini AM. and Chalot M. Trends Microbiol. 2003, 11: 53-55.
Permease recycling and ubiquitination status reveal a particular role for Bro1 in the multivesicular body pathway. Nikko E., Marini AM. and André B. Journal of Biological Chemistry 2003, 278: 50732-50743.
Yeast Npi3/Bro1 is involved in ubiquitin-dependent control of permease trafficking. Springael JY., Nikko E., André B. and Marini AM. FEBS Letters 2002, 517: 103-109.
Molecular characterization of two ammonium transporters from the ectomycorrhizal fungus Hebeloma cylindrosporum. Javelle A., Rodriguez-Pastrana BR., Jacob C., Botoon B., Brun A., André B., Marini AM. and Chalot M. FEBS Letters 2001, 505(3):393-398.
Isolation and characterisation of the Lotus japonicus AMT1;1 gene. Salvemini F., Marini AM., Riccio A., Patriarca EJ. and Chiurazzi M. Gene 2001, 270:237-243.
Cloning and expression of a putative Rh-like ammonium transporter from gills of the shore crab Carcinus maenas. Weihrauch D., Marini AM. and Towle D. American zoologist 2001, 41:1621.
Cross-talk between ammonium transporters in yeast and interference by the soybean SAT1 protein. Marini AM., Springael JY., Frommer WB. and André B. Molecular Microbiology 2000, 35: 378-385.
The human Rhesus-associated RhAG protein and a kidney homologue promote ammonium transport in yeast. Marini AM., Matassi G., Raynal V., André B., Cartron JP. and Chérif-Zahar B. Nature Genetics 2000, 26: 341-344.
In vivo N-glycosylation of the Mep2 high affinity ammonium transporter from Saccharomyces cerevisiae reveals an extracytosolic NH2 terminus. Marini AM. and André B. Molecular Microbiology 2000, 38(3): 552-564.
A family of ammonium transporters in Saccharomyces cerevisiae. Marini AM., Soussi-Boudekou S., Vissers S. and André B. Mol. Cell. Biol. 1997, 17(8):4282-4293.
The Rh (Rhesus) blood group polypeptides are related to NH4+ transporters. Marini AM., Urrestarazu A., Beauwens R. and André B. TIBS 1997, 22:460-461.
Cloning and expression of the MEP1 gene encoding an ammonium transporter in Saccharomyces cerevisiae. Marini AM., Vissers S., Urrestarazu A. and André B. The EMBO Journal 1994, 13(15): 3456-3463.

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